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| First Name: | Jin-Jing | | Last Name: | Pei | | Title: | Associate Professor | | Advanced Degrees: | PhD, MD | | Affiliation: | Karolinska Institutet | | Department: | Neurotec | | Street Address 1: | Novum plan 5 | | Street Address 2: | Geriatric-lab | | State/Province: | Stockholm | | Zip/Postal Code: | 14157 | Country/Territory: | Sweden | | Phone: | 46-8-58583649 | | Fax: | 46-8-58583880 | | Email Address: |  |
Disclosure:
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View all comments by Jin-Jing Pei
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Alzheimer Disease, Polyglutamine Disorders (Huntington's, etc.), Prion Diseases, Aging Process, Tauopathies, Parkinson Disease, Neurodevelopmental Disorders (Down syndrome, etc.), Stroke and Trauma, Neuromuscular Disorders (ALS, etc.)
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Diagnosis, Signal transduction, Brain imaging, Neuropathology, Chemistry/Pharmacology, Proteomics, A-beta PP/A-beta, Molecular and Cell biology, Drug screening, Tau/Cytoskeleton, Genetics, Microscopy, Neurobiology, Bioinformatics/Statistics, Oxidative Stress, Protein structure/chemistry, Electrophysiology, Animal Models, Apoptosis/Cell cycle, Neurotransmission, Stem cells
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Medical hospital, Research institute, University
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1.Jin-Jing Pei, Toshihisa Tanaka, Yunn-Chyn Tung, Eva Braak, Khalid Iqbal, and Inge Grundke-Iqbal. Glycogen synthase kinase-3: Distribution, Levels and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain. Journal of Neuropathology and Experimental Neurology 56 (1997): 70-78.
2.Jin-Jing Pei*, Eva Braak, Heiko Braak, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad and Richard F. Cowburn. Distribution of active glycogen synthase kinase 3b (GSK-3b) in brains staged for Alzheimer’s disease neurofibrillary changes. Journal of Neuropathology and Experimental Neurology 58 (1999): 1010-1019.
3.Jin-Jing Pei, Cheng-Xin Gong, Wen-Lin An, Bengt Winblad, Richard F. Cowburn, Inge Grundke-Iqbal, Khalid Iqbal. Okadaic acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2 and p70 S6 similar to that in Alzheimer’s disease. American Journal of Pathology 163 (2003): 845-58.
4.Jin-Jing Pei*, Sabiha Khatoon, Wen-Lin An, Maria Nordlinder, Toshihisa Tanaka, Heiko Braak, Ichiro Tsujio, Masatoshi Takeda, Irina Alafuzoff, Bengt Winblad, Richard Cowburn, Inge Grundke-Iqbal, Khalid Iqbal. Role of protein kinase B in Alzheimer's neurofibrillary degeneration. Acta Neuropathologica 105 (2003): 381-392.
5.Wen-Lin An, Richard F Cowburn, Lin Li, Heiko Braak, Irina Alafuzoff, Khalid Iqbal, Inge-Grundke Iqbal, Bengt Winblad, Jin-Jing Pei*. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer’s disease. American Journal of Pathology 163 2003): 591-607.
6.Wen-Lin An, Cecilia Bjorkdahl, Rong Liu, Richard F Cowburn, Bengt Winblad, Jin-Jing Pei*. Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3b in SH-SY5Y neuroblastoma cells. J Neurochem 92 (2005): 1104-1115.
7.Cecilia Bjorkdahl, Magnus Sjögren, Bengt Winblad B, Jin-Jing Pei*. Zinc induces neurofilament phosphorylation independent of p70 S6 kinase in N2a cells. NeuroReport 16 (2005): 591-595.
8.Xu Li, Irina Alafuzoff, Hilkka Soininen, Bengt Winblad, Jin-Jing Pei*. Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain. FEBS Journal 272 (2005):4211-20.
9.Jin-Jing Pei*, Wen-Lin An, Xin-Wen Zhou, Takeshi Nishimura, Jan Norberg, Eirkur Benedikz, Jürgen Götz, Bengt Winblad. P70 S6 kinase mediates tau phosphorylation and synthesis. FEBS Lett. 580 (2006):107-14.
10.Xinwen Zhou, Xu Li, Cecilia Bjorkdahl, Magnus J Sjogren, Irina Alafuzoff, Hilkka Soininen, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Jin-Jing Pei*. Assessments of the accumulation severities of amyloid ß-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiology of Disease (in press).
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Animal models based on the targets we have characterized |
Upregulation of protein kinases such as GSK-3 play a key role in tau tangle formation
De-regulation of mTOR /p70 S6 kinase signalling plays a dual role in tau tangle formation: tau synthesis and phosphorylation |
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